The Animal and Plant Health Agency is an Executive Agency of the UK Department for Environment, Food and Rural Affairs (Defra) with the capability and commitment to deliver a wide range of animal and public health and welfare policies for the UK. This ranges from field activity on-farm through to specialist laboratory and scientific services. Research activities underpin the surveillance work and provide robust scientific evidence required by the UK Government and international organizations (EU, OIE, WHO, FAO) to inform policy and control strategies. The AHVLA is a major partner in the following EU networks-of-excellence: ANITGONE, PIVEC, COSI, ESNIP3, FLUPIG, FLUTEST, FLURESIST, FLUTRAIN, FLU-LAB-NET, Med-Vet-Net, Epizone, EVA, NeuroPrion and ArboZooNet. The Wildlife Zoonoses and Vector Borne Diseases Group (WZVBD) at AHVLA is a World Health Organisation Communicable Disease Surveillance and Response Collaborating Centre for the characterisation of rabies and rabies-related viruses and is designated an OIE Reference Laboratory for Rabies. Research activities include a 15 year history of studies on the pathogenesis and immune response to lyssavirus infection and lyssavirus epidemiology.
ASKLEPIOS brings together eight partners from: the Netherlands, The United Kingdom, Czech Republic, Poland, Hungary and Belgium. All partners bring unique expertise and resources to ASKLEPIOS. As a whole, ASKLEPIOS combines leading experts on rabies pathogenesis from ANTIGONE and SILVER with leading research groups from Czech Republic, Poland and Hungary. The result is a highly complementary consortium that is well balanced in terms of expertise and resources and is a good reflection of the problem addressed in terms of geographic coverage.
Artemis One Health Research B.V. is a multidisciplinary institute located at the campus of Utrecht University in The Netherlands, dealing primarily with both infectious and non-infectious causes of wildlife and zoonotic diseases. The institute currently involves 10 PhD students and scholars and has thousand square meters of laboratory space and state-of-the-art facilities, allowing experiments using molecular biology, pathology and immunological techniques. Artemis BV has (animal) facilities to work with BSL2 and BSL3 agents both in vitro and in vivo including a pathology centre, imaging possibilities, cell culture facilities, flow cytometry and an experimental animal centre with biosafety level 3 capabilities, all dedicated primarily to wildlife health and directly related issues.
The Centre for Agricultural Research of the Hungarian Academy of Sciences is the largest agricultural research centre in Hungary with more than 400 employees. The Institute for Veterinary Medical Research of the Centre for Agricultural Research was founded in 1949 and since that time it has a continuously successful research history in the field of infectious diseases of animals and humans. It participated in several FP projects in the last decade (EDEN, Med-Vet-Net, EuroPathoGenom, NOVADUCK, EELREP, SUPASAL-VAC).
Viroscience Lab is the largest university medical center in The Netherlands. It is the legal entity of the Viroscience Lab that employs more than 110 employees of different disciplines and runs an extensive experimental research program on the epidemiology, pathogenesis, prevention and treatment of infections by human and animal viruses. Viroscience Lab houses the National Influenza Center and the international reference center for arboviruses and viral haemorraghic fevers for WHO. It coordinates the FP7 projects EMPERIE (223498), ANTIGONE (278976) FLUNIVAC (602604) and VECTORIE (261466) and is major partner in PREPARE (602525), SILVER (260644), iHIVARNA (602570), CHAIN ( 223131), ADITEC (280873), and PATHSEEK (304875).
Institut Pasteur (IP) is a non-profit foundation dedicated to the prevention and treatment of diseases through biomedical research, education, and public health activities. For over a century, IP has been at the forefront of the battle against infectious diseases. Organised in 10 departments IP is recognised as a leader in infectious diseases research, and ranked as a top-level institution for publication impact in the field of microbiology. Through its International network of 32 Pasteur Institutes in 27 countries IP contributes to a better detection and control of pathogens of major concern for Human and Animal Health. A high-level technology park, composed of 10 state-of-the-art technological platforms, offers cutting-edge equipment and know-how. The IP’s Teaching Centre offers a high-quality training program to young French and foreign researchers through a unique combination of high-quality theoretical, analytical and technical courses and lectures. Within the Department of Virology, the unit of “Molecular Genetics of RNA Viruses” is headed by Prof. Sylvie van der Werf. The unit is the coordinating laboratory of the French National Reference Centre for influenza and hosts the WHO National Influenza Centre (Northern-France) and WHO H5 reference laboratory. The unit currently coordinates the FP7 project PREDEMICS (278433) and participates in several other European FP7 projects (EMPERIE, FLU-PHARM, FIBEBIOTICS) as well as in the FLURISK project funded by EFSA.
The Laboratory of Virology and Chemotherapy of the Katholieke Universiteit Leuven focusses on the development of novel antiviral strategies against a number of RNA viruses including (but not limited to) HCV, flaviviruses (mainly dengue) and picornaviruses (rhinovirus inhibitors for the prevention and treatment of exacerbations of asthma and COPD by these viruses). As partner of the EU FP7 funded project SILVER (Small-molecule Inhibitor Leads Versus Emerging and Neglected Viruses) the laboratory is very active in identifying small molecule inhibitors of yet other (neglected) RNA viruses including rabies (see below). The laboratory was involved in the discovery of the anti-HCV activity of Alisporivir, a compound which was developed to phase III clinical trials at Novartis
The National Veterinary Research Institute is the scientific institution of the Ministry of Agriculture and Rural Development and the expertise institution for the CVO of Poland. Panstwowy Instytut W provides the diagnostic support for the Veterinary Inspection and is National Reference Laboratory. Major mission of the Institute is the applied research in veterinary science and medicine, monitoring of residues, heavy metals, zoonoses, zoonotic agents in food of animal origin. We provide also diagnostic services to the breeders, consumers, farmers. The Institute runs the post graduation training, classes, courses for the vet practitioners. The research activities include: aetiology, pathogenesis, diagnosis, control, and epidemiology of viral diseases; characterisation of prion protein isolated from cases of transmissible encephalopathies; molecular biology methods in the diagnosis of viral diseases; and genetic and epidemiologic analysis of viral and prion diseases in Poland. Its experts participate in organizations like EFSA, EU working groups on different topics and accommodate the OIE collaborating centers for CSF, PRRS, BLV. One of the most important tasks is the ORV of foxes against rabies – the campaigns supervised by the experts from NVRI since 1993.
Szent István Egyetem of the Faculty of Veterinary Science in Budapest is one of the oldest veterinary schools in Europe and the only veterinary school in Hungary. The virology research group of the Department of Microbiology and Infectious Diseases will carry out the investigations. The research group has been investigating the genomic characters, pathogenesis, geographic distribution and diversity of several animal viruses (including zoonotic agents). The group is involved in VECTORIE (261466) and EDENext (261504).
The Veterinary Research Institute is the leading veterinary research institute in the Czech Republic aimed at the investigation in the area of veterinary medicine including practical application of the research. Its research objectives comprise the area of broad preclinical disciplines of veterinary science including human medicine, ecology and other specializations. The Department of Virology, consists of five research groups (Viral Diseases of Fish, Viral Diseases of Cattle, Viral Diseses of Swine, Emerging Viral Infections, and Analytical Biotechnology), employs 35 employees of different disciplines and runs an extensive experimental research program on the epidemiology, pathogenesis, prevention and treatment of infections by animal and human viruses.